A laboratory test in which a patient’s serum molecules are subjected to separation according to their size and electrical charge. For myeloma patients, electrophoresis of the blood allows both the calculation of the amount of myeloma protein (m-protein) as well as the identification of the specific M-spike characteristic for each patient. Electrophoresis is used as a tool both for diagnosis and for monitoring.
In clinical trials, requirements that must be met for an individual to be included in a study. These requirements help make sure that patients in a trial are similar to each other in terms of specific factors such as age, type and stage of cancer, general health, and previous treatment. When all participants meet the same eligibility criteria, it gives researchers greater confidence that results of the study are caused by the intervention being tested and not by other factors.
ESR. The distance red blood cells travel in one hour in a sample of blood as they settle to the bottom of a test tube. The sedimentation rate is increased in inflammation, infection, cancer, rheumatic diseases, and diseases of the blood and bone marrow. Also called sedimentation rate.
A condition in which immature red blood cells (erythroid cells) in the bone marrow are abnormal in size, shape, organization, and/or number. Erythrodysplasia may be caused by vitamin deficiency or chemotherapy, or it may be a sign of refractory anemia, which is a myelodysplastic syndrome. Also called erythroid dysplasia.
A condition in which immature red blood cells (erythroid cells) in the bone marrow are abnormal in size, shape, organization, and/or number. Erythroid dysplasia may be caused by vitamin deficiency or chemotherapy, or it may be a sign of refractory anemia, which is a myelodysplastic syndrome. Also called erythrodysplasia.
A hormone produced by the kidneys. Myeloma patients with damaged kidneys don’t produce enough erythropoietin and can become anemic. Injections with synthetic erythropoietin can be helpful. Blood transfusion is another alternative, especially in an emergency. Synthetic erythropoietin is being used prophylactically before chemotherapy and as a supportive therapy after chemotherapy to avoid anemia.
In clinical trials, refers to a drug (including a new drug, dose, combination, or route of administration) or procedure that has undergone basic laboratory testing and received approval from the U. S. Food and Drug Administration (FDA) to be tested in human subjects. A drug or procedure may be approved by the FDA for use in one disease or condition, but be considered experimental in other diseases or conditions. Also called investigational.
Radiation therapy that uses a machine to aim high-energy rays at the cancer. Also called external radiation.
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