Bone marrow transplants are currently the only known possible cure for patients with myelodysplastic syndrome. These transplants replace blood-forming cells in the bone marrow that are abnormal. Healthy bone marrow “stem cells” (the “primitive” or “immature” cells that form all blood cells) are removed from the MDS patient or a donor. These reinfused stem cells help to create new bone marrow, restore blood cell production, and improve the patient’s immune system function. Bone marrow transplants can be risky and difficult on the patient, and are typically recommended for otherwise-healthy individuals. Be sure to discuss the risks and benefits of a bone marrow transplant with your doctor if you are considered a candidate for this form of treatment.
Before a transplant can take place, the MDS patient’s diseased bone marrow must first be destroyed, usually by chemotherapy and radiation. The healthy stem cells are then injected into the patient’s bloodstream in a procedure called an “infusion.” The stem cells then travel to the bone marrow, where they reproduce. Growth-stimulating factors may also be administered to help speed the regeneration of the cells in the bone marrow.
The two types of bone marrow transplantation are called “allogeneic” (meaning the stem cells come from a donor) and “autologous” (meaning the stem cells are taken by the patient). Autologous transplants are considered an experimental therapy for MDS patients.
In an allogeneic bone marrow transplant, a healthy person donates stem cells to the patient. Your medical professionals will try to find the best donor “match” for you as possible. The ideal “match” is an identical twin. Other siblings may provide a good match, as well. Unrelated donors might also be available through the National Marrow Donor Program. However, the chances of a successful outcome are much greater if the donor is related to the patient. Allogeneic bone marrow transplantation is a more common treatment in patients with aplastic anemia under the age of 30, who are more likely to tolerate the rigorous procedure.
This Web site is sponsored by the law firm of Baron & Budd, P.C. Please understand that the information provided is not medical advice, but is simply offered as a resource to help you learn about myelodysplastic syndrome (MDS) and benzene. Please discuss your health-related questions and concerns with your doctor.
Benzene can cause myelodysplastic syndrome and other disorders and blood cancers. If you have been diagnosed with myelodysplastic syndrome and would like information about your legal rights, please call us at 800-946-9646 or e-mail us at
Please also visit our glossary for helpful definitions of medical terms relating to the diagnosis and treatment of myelodysplastic syndromes.
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If you or a loved one has AML, NHL, MDS, or Aplastic Anemia and was exposed to benzene or other solvents or chemicals on the job, contact Baron & Budd for a free legal consulation.
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